Cancer cells preferentially lose small chromosomes
نویسندگان
چکیده
منابع مشابه
Chromosomes of human cancer cells.
Obvious mitotic abnormalities have long been known to occur very commonly in malignant tumours, but as a result of recent improvements in technique much more reliable cytogenetic observations are now possible. Transplantable tumours were the first to be accurately examined, and these were found to consist of populations of cells with variations around a modal (" stemline ") type which differs i...
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The prognosis of patients suffering from glioblastoma (GBM) is dismal despite multimodal therapy. Although chemotherapy with temozolomide may contain tumor growth for some months, invariable tumor recurrence suggests that cancer stem cells (CSC) maintaining these tumors persist. We have therefore investigated the effect of temozolomide on CD133(+) and CD133(-) GBM CSC lines. Although differenti...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2012
ISSN: 0020-7136
DOI: 10.1002/ijc.27924